TABLE OF CONTENT

Title Page

Certification

Dedication

Acknowledgments

Table of contents

CHAPTER ONE

1.0 INTRODUCTION

CHAPTER TWO

2.0 Adrenal Fatigue

2.1     Function of Adrenal

2.2     Assessment of Adrenal Fatigue

2.3     Adrenal Fatigue and Cortisol

2.4     Symptoms of Adrenal Fatigue

2.5     Adrenal Gland Disorders

CHAPTER THREE

3.1     Adrenal fatigue and methylation

3.2     Overview of Adrenal Gland in Relation to Fatigue

3.3     How Methylation affects Adrenal Fatigue

3.4     Relationship between methylation and fatigue

CHAPTER FOUR

SUMMARY AND CONCLUSION

4.1 Summary

4.2 Conclusion

References

CHAPTER ONE

Adrenal fatigue  syndrome (AFS) is a common diagnosis in the natural and complementary health fields. It has been stated that around 80% of the people in the western world will suffer from “adrenal fatigue” (Warren, 2016). People with a genetic predisposition  develop and elevated level of homocysteine in the blood leading to poor methylation.

Cardiovascular problems, fatigue, and depression are some of the symptoms associated with methylenetetrahydrofolate reductase (MTHFR).  Vitamin B₆, vitamin B₁₂, folic acid supplementation along with eating folate-rich foods as green leafy vegetables can help correct elevated homocysteine levels. MTHFR Mutation can also indicate signs of poor detoxification. Therefore, providing  detoxification  support can prove an effective tools for addressing the problem.

Many complementary practitioners consider that daily life can “wear down” one’s adrenal and that this leads to  depletion of adrenal hormones reserve and a life-affecting reduction in adrenal  hormones especially cortisol. It has been suggested that the hyperadrenia (over production or excretion of cortisol and other stress hormones) relate to the acute and chronic stress may eventually lead to hypoadrenia, matching the exhalation/fatigue phase of the  general adaptation syndrome (Anderson, 2008). However, many people presenting purported symptoms of adrenal fatigue show normal cortisol levels and this contention lacks reliable verification in studies, and the diagnosis of adrenal fatigue is not one defined nor recognized (Shah and Greenberger, 2013).